Organoid Biobank

The living organoid biobank created by HUB and its partners consists of more than 1000 organoid cultures representing a variety of organs and disease models. For monogenetic diseases, the HUB living organoid biobank includes intestinal and lung organoids from Cystic Fibrosis patients and liver organoids from patients with metabolic diseases (e.g. alpha-1 antitrypsin, Crigler-Najjar, etc.). The HUB living organoid biobank also has an important representation of cancer models including breast, colorectal, head and neck, intestinal, liver, lung, ovarian, pancreatic tumour organoids. For some of these cancer models, organoids derived from normal (cancer-free) adjacent tissue are also available.

Using the living organoid biobank, HUB explores novel therapeutic strategies, including responsiveness to drug combinations to develop rules for patient stratification based on drug sensitivity in vitro. Connecting genomic heterogeneity and gene function to in vitro drug responsiveness will lead to the development of a road map for improved treatment strategies.

HUB Organoid Database

HUB Organoid database consists of a catalogue of models that are present in the HUB living organoid biobank including small intestine, colon, pancreas, lung, breast, kidney, and liver. Extensive information about practical aspects of the organoid cultures and their characterization, including genetic, histological and clinical data, can be found in the organoid database, depending on the model. If available, responses to relevant drug treatments for the disease model are also provided.

The HUB Organoid database is continuously growing. Please don`t hesitate to contact us in case you can`t find your desired organoid model in our database. We are happy to assist you further.

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